The TNFAIP3 Rabbit Polyclonal Antibody from HUABIO is a Rabbit Polyclonal antibody to TNFAIP3. This antibody recognizes Human, Mouse, and Rat antigen. The TNFAIP3 Rabbit Polyclonal Antibody has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
pecifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor ┟ B (NF┟B) gene expression. By inhibiting NF┟B activation, A20 plays a critical role in terminating NF┟B responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NF┟B activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) ┚ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases